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Article

The recruitment of AMP-activated protein kinase to glycogen is regulated by autophosphorylation.

The Journal of biological chemistry - 1 May 2015

Oligschlaeger Yvonne, Miglianico Marie, Chanda Dipanjan, Scholz Roland, Thali Ramon F, Tuerk Roland, Stapleton David I, Gooley Paul R, Neumann Dietbert

Abstract excerpt

The mammalian AMP-activated protein kinase (AMPK) is an obligatory αβγ heterotrimeric complex carrying a carbohydrate-binding module (CBM) in the β-subunit (AMPKβ) capable of attaching AMPK to glycogen. Nonetheless, AMPK localizes at many different cellular compartments, implying the existence of mechanisms that prevent AMPK from glycogen binding. Cell-free carbohydrate binding assays revealed that AMPK...

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PMID: 25792737
DOI: 10.1074/jbc.M114.633271
PMCID: PMC4416872

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