Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenosine receptor subtypes and the heart failure phenotype: translating lessons from mice to man.

Transactions of the American Clinical and Climatological Association - 1 Jan 2011

Feldman Arthur M, Cheksis-Feiner Ellina, Hamad Eman, Chan Tung

Abstract excerpt

Adenosine plays an important role in the pathophysiology of heart failure and in myocardial protection during ischemia and reperfusion. The action of adenosine in the heart is mediated by four G-protein-coupled receptors: A(1)-AR and A(3)-AR, which act via Gα(1), and A(2A)-AR and A(2B)-AR, which act via Gα(s). Understanding of cellular signaling pathways triggered by adenosine has been complicated by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heart Failure
Share to Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Myocardium

Share to Signal Transduction

Share to Translational Research, Biomedical

Share to Ventricular Dysfunction, Left

Share to Ventricular Function, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 21686225
PMCID: PMC3116336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenosine receptor subtypes and the heart failure phenotype: translating lessons from mice to man.PMID 21686225Read ↗

Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issues.Semantic proximity Read ↗

Cardiac-restricted overexpression of the A(2A)-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A(1)-adenosine receptor.Semantic proximity Read ↗

Roles of alpha1A- and alpha1B-adrenoceptors in heart: insights from studies of genetically modified mice.Semantic proximity Read ↗

α1-Adrenergic Receptor Subtypes in Nonfailing and Failing Human MyocardiumSemantic proximity Read ↗

Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization.Semantic proximity Read ↗

Mechanisms of Disease: β-adrenergic receptors—alterations in signal transduction and pharmacogenomics in heart failureSemantic proximity Read ↗

Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.Semantic proximity Read ↗

Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables.Semantic proximity Read ↗

Genetic and phenotypic targeting of beta-adrenergic signaling in heart failure.Semantic proximity Read ↗

β₃-Adrenergic Signaling in Heart Failure: A Stage-Dependent Double-Edged SwordSemantic proximity Read ↗

Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury.Semantic proximity Read ↗

Nuclear GPCRs in cardiomyocytes: an insider's view of β-adrenergic receptor signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.