Article
Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation.
Developmental cell - 16 Dec 2019
Nasr Talia, Mancini Pamela, Rankin Scott A, Edwards Nicole A, Agricola Zachary N, Kenny Alan P, Kinney Jessica L, Daniels Keziah, Vardanyan Jon, Han Lu, Trisno Stephen L, Cha Sang-Wook, Wells James M, Kofron Matthew J, Zorn Aaron M
Abstract excerpt
The trachea and esophagus arise from the separation of a common foregut tube during early fetal development. Mutations in key signaling pathways such as Hedgehog (HH)/Gli can disrupt tracheoesophageal (TE) morphogenesis and cause life-threatening birth defects (TEDs); however, the underlying cellular mechanisms are unknown. Here, we use mouse and Xenopus to define the HH/Gli-dependent processes orchestrating TE...
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