Article
C560Rβ3 caused platelet integrin αII b β3 to bind fibrinogen continuously, but resulted in a severe bleeding syndrome and increased murine mortality.
Journal of thrombosis and haemostasis : JTH - 1 Jun 2013
Fang J, Nurden P, North P, Nurden A T, Du L M, Valentin N, Wilcox D A
Abstract excerpt
BACKGROUND AND OBJECTIVES: β(3)-Deficient megakaryocytes were modified by human β(3)-lentivirus transduction and transplantation to express sufficient levels of a C560Rβ(3) amino acid substitution, for investigation of how an activated αII b β(3) conformation affects platelets in vivo in mice. PATIENT/METHODS: As in our previous report of an R560β(3) mutation in a patient with Glanzmann thrombasthenia, R560β(3)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.