Article
Phenotypic clustering of yeast mutants based on kinetochore microtubule dynamics.
Bioinformatics (Oxford, England) - 1 Jul 2007
Jaqaman K, Dorn J F, Marco E, Sorger P K, Danuser G
Abstract excerpt
MOTIVATION: Kinetochores are multiprotein complexes which mediate chromosome attachment to microtubules (MTs) of the mitotic spindle. They regulate MT dynamics during chromosome segregation. Our goal is to identify groups of kinetochore proteins with similar effects on MT dynamics, revealing pathways through which kinetochore proteins transform chemical and mechanical input signals into cues of MT regulation....
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