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Article

Diversity in the Acute CD8 T Cell Response to Vaccinia Virus in Humans

1 Dec 2005

Abstract excerpt

Orthopoxviruses have complex proteomes. Infection provokes a brisk CD8 response, which is required in some systems for recovery from primary infection. Little is known concerning the Ags and epitopes recognized by CD8 T cells. We examined the fine specificity of cloned and bulk human vaccinia-specific CD8 CTL by expressing polypeptide fragments from a library of vaccinia genomic DNA. This epitope discovery method...

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PMID: 16301664
DOI: 10.4049/jimmunol.175.11.7550

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