Article
Functionally-inactive and immunogenic Tat, Rev and Nef DNA vaccines derived from sub-Saharan subtype C human immunodeficiency virus type 1 consensus sequences.
Vaccine - 19 Jan 2005
Scriba Thomas J, zur Megede Jan, Glashoff Richard H, Treurnicht Florette K, Barnett Susan W, van Rensburg Estrelita Janse
Abstract excerpt
The efficacy of cellular immune responses elicited by HIV vaccines is dependent on their strength, durability and antigenic breadth. The regulatory proteins are abundantly expressed early in the viral life cycle and CTL recognition may bring about early killing of infected cells. We synthesised D...
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