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Article

Alternative splicing and genetic variation of mhc-e: implications for rhesus cytomegalovirus-based vaccines.

Communications biology - 19 Dec 2022

Brochu Hayden, Wang Ruihan, Tollison Tammy, Pyo Chul-Woo, Thomas Alexander, Tseng Elizabeth, Law Lynn, Picker Louis J, Gale Michael, Geraghty Daniel E, Peng Xinxia

Abstract excerpt

Rhesus cytomegalovirus (RhCMV)-based vaccination against Simian Immunodeficiency virus (SIV) elicits MHC-E-restricted CD8+ T cells that stringently control SIV infection in ~55% of vaccinated rhesus macaques (RM). However, it is unclear how accurately the RM model reflects HLA-E immunobiology in humans. Using long-read sequencing, we identified 16 Mamu-E isoforms and all Mamu-E splicing junctions were detected...

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Identifiers

PMID: 36536032
DOI: 10.1038/s42003-022-04344-2
PMCID: PMC9762870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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