Article
Aged Nrf2-Null Mice Develop All Major Types of Age-Related Cataracts.
Investigative ophthalmology & visual science - 1 Dec 2021
Rowan Sheldon, Jiang Shuhong, Francisco Sarah G, Pomatto Laura C D, Ma Zhiwei, Jiao Xiaodong, Campos Maria M, Aryal Sandeep, Patel Shaili D, Mahaling Binapani, Riazuddin S Amer, Duh Elia J, Lachke Salil A, Hejtmancik J Fielding, de Cabo Rafael, FitzGerald Paul G, Taylor Allen
Abstract excerpt
Purpose: Age-related cataracts affect the majority of older adults and are a leading cause of blindness worldwide. Treatments that delay cataract onset or severity have the potential to delay cataract surgery, but require relevant animal models that recapitulate the major types of cataracts for their development. Unfortunately, few such models are available. Here, we report the lens phenotypes of aged mice...
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