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Article

Complicated biallelic inactivation of Pten in radiation-induced mouse thymic lymphomas.

Mutation research - 1 Apr 2010

Yamaguchi Yu, Takabatake Takashi, Kakinuma Shizuko, Amasaki Yoshiko, Nishimura Mayumi, Imaoka Tatsuhiko, Yamauchi Kazumi, Shang Yi, Miyoshi-Imamura Tomoko, Nogawa Hiroyuki, Kobayashi Yoshiro, Shimada Yoshiya

Abstract excerpt

Inactivation of the phosphatase and tensin homolog gene (Pten) occurs via multiple tissue-dependent mechanisms including epigenetic silencing, point mutations, insertions, and deletions. Although frequent loss of heterozygosity around the Pten locus and plausible involvement of epigenetic silencing have been reported in radiation-induced thymic lymphomas, the proportion of lymphomas with inactivated Pten and the...

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Source

Identifiers

PMID: 20060398
DOI: 10.1016/j.mrfmmm.2009.12.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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