Article
The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas.
Mutation research - 1 Sept 2015
Sunaoshi Masaaki, Amasaki Yoshiko, Hirano-Sakairi Shinobu, Blyth Benjamin J, Morioka Takamitsu, Kaminishi Mutsumi, Shang Yi, Nishimura Mayumi, Shimada Yoshiya, Tachibana Akira, Kakinuma Shizuko
Abstract excerpt
Children are considered more sensitive to radiation-induced cancer than adults, yet any differences in genomic alterations associated with age-at-exposure and their underlying mechanisms remain unclear. We assessed genome-wide DNA copy number and mutation of key tumor suppressor genes in T-cell lymphomas arising after weekly irradiation of female B6C3F1 mice with 1.2Gy X-rays for 4 consecutive weeks starting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.