Article
Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma.
Neoplasia (New York, N.Y.) - 1 Jun 2018
Wang Xiaoxiao, Cao Xin, Sun Ruifang, Tang Charlene, Tzankov Alexandar, Zhang Jun, Manyam Ganiraju C, Xiao Min, Miao Yi, Jabbar Kausar, Tan Xiaohong, Pang Yuyang, Visco Carlo, Xie Yan, Dybkaer Karen, Chiu April, Orazi Attilio, Zu Youli, Bhagat Govind, Richards Kristy L, Hsi Eric D, Choi William W L, van Krieken J Han, Huh Jooryung, Ponzoni Maurilio, Ferreri Andrés J M, Møller Michael B, Parsons Ben M, Winter Jane N, Piris Miguel A, Li Shaoying, Miranda Roberto N, Medeiros L Jeffrey, Li Yong, Xu-Monette Zijun Y, Young Ken H
Abstract excerpt
PTEN loss has been associated with poorer prognosis in many solid tumors. However, such investigation in lymphomas is limited. In this study, PTEN cytoplasmic and nuclear expression, PTEN gene deletion, and PTEN mutations were evaluated in two independent cohorts of diffuse large B-cell lymphoma (DLBCL). Cytoplasmic PTEN expression was found in approximately 67% of total 747 DLBCL cases, more frequently in the...
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