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Article

Pten dose dictates cancer progression in the prostate.

PLoS biology - 1 Dec 2003

Trotman Lloyd C, Niki Masaru, Dotan Zohar A, Koutcher Jason A, Di Cristofano Antonio, Xiao Andrew, Khoo Alan S, Roy-Burman Pradip, Greenberg Norman M, Van Dyke Terry, Cordon-Cardo Carlos, Pandolfi Pier Paolo

Abstract excerpt

Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs at presentation. To determine the consequence of PTEN dose variations on cancer progression, we have generated by homologous recombination a hypomorphic Pten mouse mutant series with decreasing Pten activity:...

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Share to Prostate
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Forkhead Box Protein O3

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Share to Hyperplasia

Share to PTEN Phosphohydrolase

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 14691534
DOI: 10.1371/journal.pbio.0000059
PMCID: PMC270016

Genes

PTEN
FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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