Article
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
Current biology : CB - 22 Oct 1998
Suzuki A, de la Pompa J L, Stambolic V, Elia A J, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M, Mak T W
Abstract excerpt
BACKGROUND: Germ-line and sporadic mutations in the tumor suppressor gene PTEN (also known as MMAC or TEP1), which encodes a dual-specificity phosphatase, cause a variety of cancers such as Cowden disease, glioblastoma, endometrial carcinoma and prostatic cancer. PTEN is widely expressed, and Cow...
Topics
- Animals
- Embryonic and Fetal Development
- Exons
- Female
- Fetal Death
- Gamma Rays
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Genotype
- Lymphoma, T-Cell
- Mice
- Mice, Mutant Strains
- Neoplasms
- PTEN Phosphohydrolase