Article
Hyperphosphorylated PTEN exerts oncogenic properties.
Nature communications - 24 May 2023
van Ree Janine H, Jeganathan Karthik B, Fierro Velasco Raul O, Zhang Cheng, Can Ismail, Hamada Masakazu, Li Hu, Baker Darren J, van Deursen Jan M
Abstract excerpt
PTEN is a multifaceted tumor suppressor that is highly sensitive to alterations in expression or function. The PTEN C-tail domain, which is rich in phosphorylation sites, has been implicated in PTEN stability, localization, catalytic activity, and protein interactions, but its role in tumorigenesis remains unclear. To address this, we utilized several mouse strains with nonlethal C-tail mutations. Mice homozygous...
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