Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis.

Journal of molecular medicine (Berlin, Germany) - 1 Apr 2010

Wieczorek Stefan, Holle Julia U, Müller Stephanie, Fricke Harald, Gross Wolfgang L, Epplen Jörg T

Abstract excerpt

Wegener's granulomatosis (WG), characterized by systemic vasculitis and granulomatous inflammation, is a rare chronic rheumatic condition potentially sharing some etiopathological principles with other autoimmune disorders, e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Several large association studies have identified genetic risk factors for RA and SLE. Thereof, we have evaluated the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmunity
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Granulomatosis with Polyangiitis

Share to Inflammation

Share to Interferon Regulatory Factors

Share to Odds Ratio

Source

Identifiers

PMID: 20049410
DOI: 10.1007/s00109-009-0580-y

Genes

CDK6
TNFAIP3
CCL21
KLF12
MMEL1
PRKCQ
STAT4
TRAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis.PMID 20049410Read ↗

Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population.Semantic proximity Read ↗

IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups.Semantic proximity Read ↗

Defining genetic risk factors for scleroderma-associated interstitial lung disease : IRF5 and STAT4 gene variants are associated with scleroderma while STAT4 is protective against scleroderma-associated interstitial lung disease.Semantic proximity Read ↗

Association of IRF5, STAT4 and BLK with systemic lupus erythematosus and other rheumatic diseases.Semantic proximity Read ↗

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.Semantic proximity Read ↗

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.Semantic proximity Read ↗

Genetics research in systemic lupus erythematosus for clinicians: methodology, progress, and controversies.Semantic proximity Read ↗

Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis.Semantic proximity Read ↗

Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory GenesSemantic proximity Read ↗

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.Semantic proximity Read ↗

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.Semantic proximity Read ↗

Analysis of IRF5 gene functional polymorphisms in rheumatoid arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.