Article
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
Nature genetics - 1 Nov 2013
Lessard Christopher J, Li He, Adrianto Indra, Ice John A, Rasmussen Astrid, Grundahl Kiely M, Kelly Jennifer A, Dozmorov Mikhail G, Miceli-Richard Corinne, Bowman Simon, Lester Sue, Eriksson Per, Eloranta Maija-Leena, Brun Johan G, Gøransson Lasse G, Harboe Erna, Guthridge Joel M, Kaufman Kenneth M, Kvarnström Marika, Jazebi Helmi, Cunninghame Graham Deborah S, Grandits Martha E, Nazmul-Hossain Abu N M, Patel Ketan, Adler Adam J, Maier-Moore Jacen S, Farris A Darise, Brennan Michael T, Lessard James A, Chodosh James, Gopalakrishnan Rajaram, Hefner Kimberly S, Houston Glen D, Huang Andrew J W, Hughes Pamela J, Lewis David M, Radfar Lida, Rohrer Michael D, Stone Donald U, Wren Jonathan D, Vyse Timothy J, Gaffney Patrick M, James Judith A, Omdal Roald, Wahren-Herlenius Marie, Illei Gabor G, Witte Torsten, Jonsson Roland, Rischmueller Maureen, Rönnblom Lars, Nordmark Gunnel, Ng Wan-Fai, Mariette Xavier, Anaya Juan-Manuel, Rhodus Nelson L, Segal Barbara M, Scofield R Hal, Montgomery Courtney G, Harley John B, Sivils Kathy L
Abstract excerpt
Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 ×...
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