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Article

Analysis of IRF5 gene functional polymorphisms in rheumatoid arthritis.

Arthritis and rheumatism - 1 Dec 2006

Rueda Blanca, Reddy M V Prasad Linga, González-Gay Miguel A, Balsa Alejandro, Pascual-Salcedo Dora, Petersson Ingemar F, Eimon Alicia, Paira Sergio, Scherbarth Hugo R, Pons-Estel Bernardo A, González-Escribano Maria F, Alarcón-Riquelme Marta E, Martín Javier

Abstract excerpt

OBJECTIVE: Recent findings suggest that interferon regulatory factor 5 (IRF-5) may play a crucial role in several cellular processes, including the transcription of genes for inflammatory cytokines. Two genetic variants of the IRF5 gene (rs2004640 in exon 1 and rs2280714 in the 3'-untranslated region) have been shown to exert functional modifications affecting IRF5 messenger RNA splicing and expression, and have...

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PMID: 17133578
DOI: 10.1002/art.22271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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