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Article

Association of IRF5, STAT4 and BLK with systemic lupus erythematosus and other rheumatic diseases.

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology - 1 Jan 2010

Tsuchiya Naoyuki, Ito Ikue, Kawasaki Aya

Abstract excerpt

Recent large-scale studies in the Caucasian populations identified many new susceptibility genes to systemic lupus erythematosus (SLE). In this review, we discuss our findings on some of such genes, interferon regulatory factor 5 (IRF5), signal transducer and activator of transcription 4 (STAT4)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20453440
DOI: 10.2177/jsci.33.57

Genes

BLK
STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20453440-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Association of IRF5, STAT4 and BLK with systemic lupus erythematosus and other rheumatic diseases.PMID 20453440Read ↗

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Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms.Semantic proximity Read ↗

Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population.Semantic proximity Read ↗

Variants in the interferon regulatory factor 5 gene confer genetic risk for systemic lupus erythematosus in a Han Chinese population.Semantic proximity Read ↗

Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population.Semantic proximity Read ↗

IRF5-mediated signaling and implications for SLE.Semantic proximity Read ↗

Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.Semantic proximity Read ↗

A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population.Semantic proximity Read ↗

Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4.Semantic proximity Read ↗

Different genetic effects of interferon regulatory factor 5 (IRF5) polymorphisms on systemic lupus erythematosus in a Korean population.Semantic proximity Read ↗

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.Semantic proximity Read ↗

No evidence for a genetic association of IRF4 with systemic lupus erythematosus in a Chinese population.Semantic proximity Read ↗

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