Article
Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population.
Rheumatology (Oxford, England) - 1 Jan 2012
Järvinen Tiina M, Hellquist Anna, Zucchelli Marco, Koskenmies Sari, Panelius Jaana, Hasan Taina, Julkunen Heikki, D'Amato Mauro, Kere Juha
Abstract excerpt
OBJECTIVE: A large number of genes, including several not previously implicated in SLE susceptibility, have recently been identified or confirmed by genome-wide association studies (GWAS). In this study, we sought to replicate some of these results in Finnish SLE patients (n = 275) and control individuals (n = 356). METHODS: We genotyped 32 single nucleotide polymorphisms (SNPs) in 12 of the best-supported...
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