Article
The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.
Human molecular genetics - 15 Jan 2015
Kottyan Leah C, Zoller Erin E, Bene Jessica, Lu Xiaoming, Kelly Jennifer A, Rupert Andrew M, Lessard Christopher J, Vaughn Samuel E, Marion Miranda, Weirauch Matthew T, Namjou Bahram, Adler Adam, Rasmussen Astrid, Glenn Stuart, Montgomery Courtney G, Hirschfield Gideon M, Xie Gang, Coltescu Catalina, Amos Chris, Li He, Ice John A, Nath Swapan K, Mariette Xavier, Bowman Simon, Rischmueller Maureen, Lester Sue, Brun Johan G, Gøransson Lasse G, Harboe Erna, Omdal Roald, Cunninghame-Graham Deborah S, Vyse Tim, Miceli-Richard Corinne, Brennan Michael T, Lessard James A, Wahren-Herlenius Marie, Kvarnström Marika, Illei Gabor G, Witte Torsten, Jonsson Roland, Eriksson Per, Nordmark Gunnel, Ng Wan-Fai, Anaya Juan-Manuel, Rhodus Nelson L, Segal Barbara M, Merrill Joan T, James Judith A, Guthridge Joel M, Scofield R Hal, Alarcon-Riquelme Marta, Bae Sang-Cheol, Boackle Susan A, Criswell Lindsey A, Gilkeson Gary, Kamen Diane L, Jacob Chaim O, Kimberly Robert, Brown Elizabeth, Edberg Jeffrey, Alarcón Graciela S, Reveille John D, Vilá Luis M, Petri Michelle, Ramsey-Goldman Rosalind, Freedman Barry I, Niewold Timothy, Stevens Anne M, Tsao Betty P, Ying Jun, Mayes Maureen D, Gorlova Olga Y, Wakeland Ward, Radstake Timothy, Martin Ezequiel, Martin Javier, Siminovitch Katherine, Moser Sivils Kathy L, Gaffney Patrick M, Langefeld Carl D, Harley John B, Kaufman Kenneth M
Abstract excerpt
Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian and frequentist approaches to model the IRF5-TNPO3 locus association, now implicated in two immunotherapies and seven autoimmune diseases. Specifically, in systemic lupus erythematosus (SLE), we resolved separate associations in the IRF5 promoter (all ancestries) and with an extended European haplotype. We captured...
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