Article
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 2005
Dani Vardhan S, Chang Qiang, Maffei Arianna, Turrigiano Gina G, Jaenisch Rudolf, Nelson Sacha B
Abstract excerpt
Rett Syndrome (RTT) is a devastating neurological disorder that is caused by mutations in the MECP2 gene. Mecp2-mutant mice have been used as a model system to study the disease mechanism. Our previous work has suggested that MeCP2 malfunction in neurons is the primary cause of RTT in the mouse. However, the neurophysiological consequences of MeCP2 malfunction remain obscure. Using whole-cell patch-clamp...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.