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Article

Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT.

Neurobiology of disease - 1 May 2015

Li Quan, Loh Dawn H, Kudo Takashi, Truong Danny, Derakhshesh Matthew, Kaswan Zoë MacDowell, Ghiani Cristina A, Tsoa Rosemarie, Cheng Yin, Sun Yi E, Colwell Christopher S

Abstract excerpt

Disturbances in the sleep/wake cycle are prevalent in patients with Rett syndrome (RTT). We sought to determine whether the circadian system is disrupted in a RTT model, Mecp2(-/y) mice. We found that MeCP2 mutants showed decreased strength and precision of daily rhythms of activity coupled with extremely fragmented sleep. The central circadian clock (suprachiasmatic nucleus) exhibited significant reduction in...

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Source

Identifiers

PMID: 25779967
DOI: 10.1016/j.nbd.2015.03.009

Genes

VIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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