Article

Loss of MeCP2 leads to sleep deficits that are time-of-day dependent and worsen with sleep deprivation

2025-04-17

Abstract excerpt

Rett syndrome (RTT) is a severe, progressive neurodevelopmental disorder caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MECP2). Sleep problems are frequently reported in Rett Syndrome, but the exact nature remains relatively unexplored. Currently there is limited understanding the role of MECP2 in sleep architecture and regulation. In this study, we employed longitudinal electroenc...

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Literature Corpus work: 793063b2-0f71-5e5a-a776-bc5ed39edd67
DOI: 10.1101/2025.04.16.649209

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Loss of MeCP2 leads to sleep deficits that are time-of-day dependent and worsen with sleep deprivationDOI 10.1101/2025.04.16.649209Read

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