Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MeCP2+/- mouse model of RTT reproduces auditory phenotypes associated with Rett syndrome and replicate select EEG endophenotypes of autism spectrum disorder.

Neurobiology of disease - 1 Apr 2012

Liao Wenlin, Gandal Michael J, Ehrlichman Richard S, Siegel Steven J, Carlson Greg C

Abstract excerpt

Impairments in cortical sensory processing have been demonstrated in Rett syndrome (RTT) and Autism Spectrum Disorders (ASD) and are thought to contribute to high-order phenotypic deficits. However, underlying pathophysiological mechanisms for these abnormalities are unknown. This study investigated auditory sensory processing in a mouse model of RTT with a heterozygous loss of MeCP2 function. Cortical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child Development Disorders, Pervasive
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electroencephalography

Share to Evoked Potentials, Auditory

Share to Methyl-CpG-Binding Protein 2

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Rett Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 22249109
DOI: 10.1016/j.nbd.2011.12.048
PMCID: PMC3299908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MeCP2+/- mouse model of RTT reproduces auditory phenotypes associated with Rett syndrome and replicate select EEG endophenotypes of autism spectrum disorder.PMID 22249109Read ↗

Sensory evoked potentials in patients with Rett syndrome through the lens of animal studies: Systematic review.Semantic proximity Read ↗

Auditory evoked-potential abnormalities in a mouse model of 22q11.2 Deletion Syndrome and their interactions with hearing impairmentSemantic proximity Read ↗

Visual evoked potentials detect cortical processing deficits in Rett syndrome.Semantic proximity Read ↗

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome.Semantic proximity Read ↗

Alterations of cortical and hippocampal EEG activity in MeCP2-deficient mice.Semantic proximity Read ↗

Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses.Semantic proximity Read ↗

Reviewing Evidence for the Relationship of EEG Abnormalities and RTT Phenotype Paralleled by Insights from Animal Studies.Semantic proximity Read ↗

Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model.Semantic proximity Read ↗

Shared and divergent alteration of whole-brain connectivity and sensory deficits in multiple autism mouse models.Semantic proximity Read ↗

Mecp2 deletion results in profound alterations of developmental and adult functional connectivitySemantic proximity Read ↗

Hippocampal circuit abnormalities in MeCP2+/- mouse model of Rett syndromeSemantic proximity Read ↗

Auditory processing atypicalities for pure tones and complex speech sounds in Rett Syndrome – towards neuromarkers of disease progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.