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<i>Helicobacter pylori</i> Induces MAPK Phosphorylation and AP-1 Activation via a NOD1-Dependent Mechanism

1 Dec 2009

Abstract excerpt

Helicobacter pylori rapidly activates MAPKs and transcription factors, NF-kappaB and AP-1, in gastric epithelial cells following host attachment. Activation of these signal transducers is largely dependent on the cag pathogenicity island (cagPAI)-encoded Type IV Secretion System. H. pylori was shown to translocate peptidoglycan through the Type IV Secretion System, which is recognized by the pathogen recognition...

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PMID: 20007577
DOI: 10.4049/jimmunol.0900664

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