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Unveiling the crucial role of type IV secretion system and motility of <i>Helicobacter pylori</i> in IL-1β production via NLRP3 inflammasome activation in neutrophils

2019-08-13

Abstract excerpt

<h4>ABSTRACT</h4> Helicobacter pylori is a gram-negative, microaerophilic, and spiral-shaped bacterium and causes gastrointestinal diseases in human. IL-1β is a representative cytokine produced in innate immune cells and is considered to be a key factor in the development of gastrointestinal malignancies. However, the mechanism of IL-1β production by neutrophils during H. pylori infection is still unknown. We de...

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Literature Corpus work
1ea4ce2c-9e67-59ec-aa3b-377e0cf6bb64
DOI
10.1101/733790
Open publication

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