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Macrophages recognize the Helicobacter pylori type IV secretion system in the absence of toll-like receptor signalling

4 Aug 2015

Abstract excerpt

Helicobacter pylori strains carrying the cag pathogenicity island (cagPAI) provoke an increased inflammatory response, conferring an increased risk of ulcer formation and carcinogenesis. How the immune system recognizes the presence of cagPAI positive strains is yet unclear. By comparing the transcriptional response of wild type and MyD88/Trif(-/-) bone marrow macrophages to infection with H. pylori, we found...

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PMID: 26243717
DOI: 10.1111/cmi.12492

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