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Modification of <i>Helicobacter pylori</i> Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach

2 Mar 2015

Abstract excerpt

Helicobacter pylori (H. pylori) is the strongest known risk factor for gastric carcinogenesis. One cancer-linked locus is the cag pathogenicity island, which translocates components of peptidoglycan into host cells. NOD1 is an intracellular immune receptor that senses peptidoglycan from Gram-negative bacteria and responds by inducing autophagy and activating NF-κB, leading to inflammation-mediated bacterial...

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PMID: 25732381
DOI: 10.1158/0008-5472.can-14-2291

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