A systematic review and meta-analysis of the impact of WT1 polymorphism rs16754 in the effectiveness of standard chemotherapy in patients with acute myeloid leukemia.

doi:10.1038/tpj.2015.80

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Article

A systematic review and meta-analysis of the impact of WT1 polymorphism rs16754 in the effectiveness of standard chemotherapy in patients with acute myeloid leukemia.

The pharmacogenomics journal - 1 Feb 2016

Megías-Vericat J E, Herrero M J, Rojas L, Montesinos P, Bosó V, Moscardó F, Martínez-Cuadrón D, Poveda J L, Sanz M Á, Aliño S F

Abstract excerpt

The polymorphism rs16754 of the WT1 gene has been described as a possible prognostic marker in different acute myeloid leukemia (AML) cohorts; however, it is not supported by all the studies. We performed the first meta-analysis evaluating the effect of this polymorphism upon the effectiveness of standard AML therapy. Fourteen cohort studies were included (3618 patients). Patients with the variant allele showed a...

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PMID: 26644203
DOI: 10.1038/tpj.2015.80

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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