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Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability.

DNA repair - 4 Feb 2010

Zakaria Chadi, Kassahun Henok, Yang Xiaoming, Labbé Jean-Claude, Nilsen Hilde, Ramotar Dindial

Abstract excerpt

We previously showed that Caenorhabditis elegans APN-1, the only metazoan apurinic/apyrimidinc (AP) endonuclease belonging to the endonuclease IV family, can functionally rescue the DNA repair defects of Saccharomyces cerevisiae mutants completely lacking AP endonuclease/3'-diesterase activities. While this complementation study provided the first evidence that APN-1 possesses the ability to act on DNA lesions...

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PMID: 20036200
DOI: 10.1016/j.dnarep.2009.11.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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