Article
Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans.
DNA repair - 1 Jan 2018
Kassahun Henok, SenGupta Tanima, Schiavi Alfonso, Maglioni Silvia, Skjeldam Hanne K, Arczewska Katarzyna, Brockway Nicole L, Estes Suzanne, Eide Lars, Ventura Natascia, Nilsen Hilde
Abstract excerpt
Oxidation of DNA bases, an inevitable consequence of oxidative stress, requires the base excision repair (BER) pathway for repair. Caenorhabditis elegans is a well-established model to study phenotypic consequences and cellular responses to oxidative stress. To better understand how BER affects phenotypes associated with oxidative stress, we characterised the C. elegans nth-1 mutant, which lack the only DNA...
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