Article
Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans.
Science (New York, N.Y.) - 22 Nov 2002
Wang Xiaochen, Yang Chonglin, Chai Jijie, Shi Yigong, Xue Ding
Abstract excerpt
Apoptosis-inducing factor (AIF), a mitochondrial oxidoreductase, is released into the cytoplasm to induce cell death in response to apoptotic signals. However, the mechanisms underlying this process have not been resolved. We report that inactivation of the Caenorhabditis elegans AIF homolog wah-1 by RNA interference delayed the normal progression of apoptosis and caused a defect in apoptotic DNA degradation....
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Apoptosis Inducing Factor
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Caspases
- Cell Nucleus
- Cell Survival
- Cloning, Molecular
- Cytosol