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Article

Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation.

Molecular and cellular biology - 1 Sept 1991

Ramotar D, Popoff S C, Gralla E B, Demple B

Abstract excerpt

The APN1 gene of Saccharomyces cerevisiae encodes the major apurinic/apyrimidinic endonuclease and 3'-repair DNA diesterase in yeast cell extracts. The Apn1 protein is a homolog of Escherichia coli endonuclease IV, which functions in the repair of some oxidative and alkylation damages in that org...

Topics

Alkylating Agents
Alkylation
Centrifugation, Density Gradient
DNA Damage
DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA-Directed DNA Polymerase
Deoxyribonuclease IV (Phage T4-Induced)
Endodeoxyribonucleases
Escherichia coli Proteins
Genes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydrogen Peroxide

Methyl Methanesulfonate

Mutation

Oxidation-Reduction

Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 1715020
DOI: 10.1128/mcb.11.9.4537-4544.1991
PMCID: PMC361329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1715020-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation.PMID 1715020Read ↗

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