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Article

Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation.

Molecular and cellular biology - 1 Sept 1991

Ramotar D, Popoff S C, Gralla E B, Demple B

Abstract excerpt

The APN1 gene of Saccharomyces cerevisiae encodes the major apurinic/apyrimidinic endonuclease and 3'-repair DNA diesterase in yeast cell extracts. The Apn1 protein is a homolog of Escherichia coli endonuclease IV, which functions in the repair of some oxidative and alkylation damages in that organism. We show here that yeast strains lacking Apn1 (generated by targeted gene disruption or deletion-replacement) are...

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Identifiers

PMID: 1715020
DOI: 10.1128/mcb.11.9.4537-4544.1991
PMCID: PMC361329

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