Article
Trans-complementation by human apurinic endonuclease (Ape) of hypersensitivity to DNA damage and spontaneous mutator phenotype in apn1-yeast.
Nucleic acids research - 25 Dec 1995
Wilson D M, Bennett R A, Marquis J C, Ansari P, Demple B
Abstract excerpt
Abasic (AP) sites in DNA are potentially lethal and mutagenic. 'Class II' AP endonucleases initiate the repair of these and other DNA lesions. In yeast, the predominant enzyme of this type is Apn1, and its elimination sensitizes the cells to killing by simple alkylating agents or oxidants, and ra...
Topics
- DNA Damage
- DNA Repair Enzymes
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Deoxyribonuclease IV (Phage T4-Induced)
- Endodeoxyribonucleases
- Gene Transfer Techniques
- Genetic Complementation Test
- Humans
- Lyases
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins