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Article

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

Blood - 15 Jul 2005

Growney Joseph D, Shigematsu Hirokazu, Li Zhe, Lee Benjamin H, Adelsperger Jennifer, Rowan Rebecca, Curley David P, Kutok Jeffery L, Akashi Koichi, Williams Ifor R, Speck Nancy A, Gilliland D Gary

Abstract excerpt

Homozygous loss of function of Runx1 (Runt-related transcription factor 1 gene) during murine development results in an embryonic lethal phenotype characterized by a complete lack of definitive hematopoiesis. In light of recent reports of disparate requirements for hematopoietic transcription factors during development as opposed to adult hematopoiesis, we used a conditional gene-targeting strategy to effect the...

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Identifiers

PMID: 15784726
DOI: 10.1182/blood-2004-08-3280
PMCID: PMC1895175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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