Article
C-terminal mutation of RUNX1 attenuates the DNA-damage repair response in hematopoietic stem cells.
Leukemia - 1 Feb 2012
Satoh Y, Matsumura I, Tanaka H, Harada H, Harada Y, Matsui K, Shibata M, Mizuki M, Kanakura Y
Abstract excerpt
Loss-of-function mutations of RUNX1 have been found in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDSs). Although several reports have suggested roles for RUNX1 as a tumor suppressor, its precise function remains unknown. Because gene alterations of RUNX1 by themselves do not lead to the development of leukemia in mouse models, additional mutation(s) would be required for leukemia development....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.