Article
Gatekeeper function of the RUNX1 transcription factor in acute leukemia.
Blood cells, molecules & diseases - 1 Jan 2000
Niebuhr Birte, Fischer Meike, Täger Maike, Cammenga Jörg, Stocking Carol
Abstract excerpt
The RUNX1 gene encodes the alpha subunit of the core binding factor (CBF) and is a common target of genetic mutations in acute leukemia. We propose that RUNX1 is a gatekeeper gene, the disruption of which leads to the exodus of a subset of hematopoietic progenitors with increased self-renewal potential from the normal environmental controls of homeostasis. This pool of "escaped" cells is the target of secondary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.