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Article

RUNX1 C-terminal mutations impair blood cell differentiation by perturbing specific enhancer-promoter networks.

Blood advances - 28 May 2024

Jayne Nathan D, Liang Zhengyu, Lim Do-Hwan, Chen Poshen B, Diaz Cristina, Arimoto Kei-Ichiro, Xia Lingbo, Liu Mengdan, Ren Bing, Fu Xiang-Dong, Zhang Dong-Er

Abstract excerpt

ABSTRACT: The transcription factor RUNX1 is a master regulator of hematopoiesis and is frequently mutated in myeloid malignancies. Mutations in its runt homology domain (RHD) frequently disrupt DNA binding and result in loss of RUNX1 function. However, it is not clearly understood how other RUNX1 mutations contribute to disease development. Here, we characterized RUNX1 mutations outside of the RHD. Our analysis...

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Share to Blood Cells
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Enhancer Elements, Genetic

Share to Gene Expression Regulation

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Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 38513139
DOI: 10.1182/bloodadvances.2023011484
PMCID: PMC11112616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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