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Article

Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins

11 Nov 2002

Abstract excerpt

Leukemic disease can be linked to aberrant gene expression. This often is the result of molecular alterations in transcription factors that lead to their misrouting within the nucleus. The acute myelogenous leukemia-related fusion protein AML1ETO is a striking example. It originates from a gene rearrangement t(8;21) that fuses the N-terminal part of the key hematopoietic regulatory factor AML1 (RUNX1) to the ETO...

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PMID: 12427969
DOI: 10.1073/pnas.242588499

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Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteinsPMID 12427969Read ↗

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