Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Core binding factor at the crossroads: Determining the fate of the HSC

7 Oct 2009

Abstract excerpt

Hematopoietic development requires coordinated actions from a variety of transcription factors. The core binding factor (CBF), consisting of a Runx protein and the CBFbeta protein, is a transcription factor complex that is essential for emergence of the hematopoietic stem cell (HSC) from an endothelial cell stage. The hematopoietic defects observed in either Runx1 or CBFbeta knockout mice underscore the necessity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Zebrafish Biomedical Research Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19813271
DOI: 10.1002/jcp.21950

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Core binding factor at the crossroads: Determining the fate of the HSCPMID 19813271Read ↗

Core binding factor and its role in normal hematopoietic developmentSemantic proximity Read ↗

The core-binding factor beta subunit is required for bone formation and hematopoietic maturation.Semantic proximity Read ↗

Runx transcription factors in the development and function of the definitive hematopoietic system.Semantic proximity Read ↗

Hematopoietic stem cell emergence in the conceptus and the role of Runx1Semantic proximity Read ↗

Deletion of core-binding factor β (Cbfβ) in mesenchymal progenitor cells provides new insights into Cbfβ/Runxs complex function in cartilage and bone developmentSemantic proximity Read ↗

Cbfβ: A key regulator in skeletal stem cell differentiation, bone development, and diseaseSemantic proximity Read ↗

T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage.Semantic proximity Read ↗

Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignanciesSemantic proximity Read ↗

Core binding factor genes and human leukemia.Semantic proximity Read ↗

Cbfbeta interacts with Runx2 and has a critical role in bone development.Semantic proximity Read ↗

Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.Semantic proximity Read ↗

Core Binding Factor Acute Myeloid Leukemia: New Prognostic Categories and Therapeutic Opportunities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.