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Article

Tumor suppressor Fhit protein interacts with protoporphyrin IX in vitro and enhances the response of HeLa cells to photodynamic therapy.

Journal of photochemistry and photobiology. B, Biology - 3 Jan 2007

Zawacka-Pankau Joanna, Kowalska Agnieszka, Issaeva Natalia, Burcza Anna, Kwiek Piotr, Bednarz Natalia, Pramanik Aladdin, Banecki Bogdan, Podhajska Anna J

Abstract excerpt

Fhit, the product of tumor suppressor fragile histidine triad (FHIT) gene, exhibits antitumor activity of still largely unknown cellular background. However, it is believed that Fhit-Ap(3)A or Fhit-AMP complex might act as a second class messenger in cellular signal transduction pathway involved in cell proliferation and apoptosis. We demonstrate here for the first time that the photosensitizer, protoporphyrin IX...

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Identifiers

PMID: 16990010
DOI: 10.1016/j.jphotobiol.2006.08.005

Genes

FHIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Tumor suppressor Fhit protein interacts with protoporphyrin IX in vitro and enhances the response of HeLa cells to photodynamic therapy.PMID 16990010Read ↗

Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit.Semantic proximity Read ↗

Expression and simple, one-step purification of fragile histidine triad (Fhit) tumor suppressor mutant forms in Escherichia coli and their interaction with protoporphyrin IX.Semantic proximity Read ↗

Fragile histidine triad protein: structure, function, and its association with tumorogenesis.Semantic proximity Read ↗

Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.Semantic proximity Read ↗

Do FHIT gene alterations play a role in human solid tumors?Semantic proximity Read ↗

Mutation and abnormal expression of the fragile histidine triad gene in nasopharyngeal carcinoma.Semantic proximity Read ↗

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Protoporphyrin IX Interacts with Wild-type p53 Protein in Vitro and Induces Cell Death of Human Colon Cancer Cells in a p53-dependent and -independent MannerSemantic proximity Read ↗

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.Semantic proximity Read ↗

Restoration of fragile histidine triad ( <i>FHIT</i> ) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell linesSemantic proximity Read ↗

The tumor suppressor Fhit acts as a repressor of β-catenin transcriptional activitySemantic proximity Read ↗

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