Article
[Mutations of fragile histidine triad gene in Peutz-Jeghers syndrome and canceration].
Ai zheng = Aizheng = Chinese journal of cancer - 1 Jan 2003
Zhao Xi-Rong, Kang Lian-Chun, Zhou Yong-Shuang, Jia Yi-Xing, Chen Zhu, Kang Su-Hai, Li Wen-Mei, Zhao Min, Cui Jian-Tao, Sun An-Le, Lu You-Yong
Abstract excerpt
BACKGROUND & OBJECTIVE: Peutz-Jeghers syndrome (PJS) is an autosomal dominantly inherited disease. Fragile histidine triad (FHIT) gene is an important tumor suppressor gene at the fragile sites region of 3p14. The authors' previous study suggested that PJS patients might have a susceptible gene at the region of 3p14.2. This study was designed to reveal the relationship between the variant of FHIT gene in PJS and...
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