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Article

Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.

The Journal of biological chemistry - 9 Jan 2009

Pichiorri Flavia, Okumura Hiroshi, Nakamura Tatsuya, Garrison Preston N, Gasparini Pierluigi, Suh Sung-Suk, Druck Teresa, McCorkell Kelly A, Barnes Larry D, Croce Carlo M, Huebner Kay

Abstract excerpt

We have previously shown that Fhit tumor suppressor protein interacts with Hsp60 chaperone machinery and ferredoxin reductase (Fdxr) protein. Fhit-effector interactions are associated with a Fhit-dependent increase in Fdxr stability, followed by generation of reactive oxygen species and apoptosis...

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Source

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Identifiers

PMID: 19004824
DOI: 10.1074/jbc.M806638200
PMCID: PMC2613607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19004824-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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