Article
Impact of FHIT loss on the translation of cancer-associated mRNAs.
Molecular cancer - 28 Dec 2017
Kiss Daniel L, Baez William, Huebner Kay, Bundschuh Ralf, Schoenberg Daniel R
Abstract excerpt
BACKGROUND: FHIT is a genome caretaker/tumor suppressor that is silenced in >50% of cancers. Although it was identified more than 20 years ago, questions remain as to how FHIT loss contributes to cancer, and conversely, how FHIT acts to maintain genome integrity and suppress malignancy. Fhit belongs to the histidine triad family of enzymes that catalyze the degradation of nucleoside 5',5'-triphosphates, including...
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