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Article

Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine.

Rheumatology (Oxford, England) - 1 Jan 2004

Clunie G P R, Lennard L

Abstract excerpt

Azathioprine (AZA) is widely used in the management of rheumatological diseases. Despite its efficacy, AZA can often cause bone marrow suppression, notably leucopenia, which has been recorded in up to 17% of patients taking AZA for rheumatoid arthritis, though this can be considered clinically significant in about 3% overall. Severe myelosuppression, associated with abnormal AZA metabolism, is linked to the...

Topics

Antirheumatic Agents
Arthritis, Rheumatoid
Azathioprine
Biomarkers
Erythrocytes
Genotype
Humans
Leukopenia
Mercaptopurine
Methyltransferases
Pharmacogenetics
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14566029
DOI: 10.1093/rheumatology/keg442

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine.PMID 14566029Read ↗

Genetic polymorphisms of thiopurine S-methyltransferase in a cohort of patients with systemic autoimmune diseases.Semantic proximity Read ↗

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Clinical pharmacogenomics of thiopurine S-methyltransferase.Semantic proximity Read ↗

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?Semantic proximity Read ↗

Utility of assessing thiopurine S-methyltransferase polymorphisms before azathioprine therapy.Semantic proximity Read ↗

The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.Semantic proximity Read ↗

Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment responseSemantic proximity Read ↗

Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine.Semantic proximity Read ↗

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Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.Semantic proximity Read ↗

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