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Article

[Usefulness of thiopurine methyltransferase polymorphism study and metabolites measurement for patients treated by azathioprine].

La Revue de medecine interne - 1 Jun 2018

Guillotin V, Galli G, Viallard J-F

Abstract excerpt

Azathioprine is widely used in internal medicine and frequently implicated in occurrence of adverse events. Among these adverse events the bone marrow suppression, a dose-related one, is the most serious because of is potential morbidity and mortality. Severe myelosuppression, associated with abnormal AZA metabolism, is linked to the thiopurine methyltransferase (TPMT) genetic polymorphism that results in a high...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Methyltransferases

Share to Polymorphism, Genetic

Share to Predictive Value of Tests

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Source

Identifiers

PMID: 29370945
DOI: 10.1016/j.revmed.2017.12.007

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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