Article
Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice.
The pharmacogenomics journal - 1 Oct 2020
Anandi Prathima, Dickson Alyson L, Feng QiPing, Wei Wei-Qi, Dupont William D, Plummer Dale, Liu Ge, Octaria Rany, Barker Katherine A, Kawai Vivian K, Birdwell Kelly, Cox Nancy J, Hung Adriana, Stein C Michael, Chung Cecilia P
Abstract excerpt
Leukopenia is a serious, frequent side effect associated with azathioprine use. Currently, we use thiopurine methyltransferase (TPMT) testing to predict leukopenia in patients taking azathioprine. We hypothesized that a risk score incorporating additional clinical and genetic variables would improve the prediction of azathioprine-associated leukopenia. In the discovery phase, we developed four risk score models:...
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