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Article

Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming.

Nature medicine - 1 Jan 2010

Kwakkenbos Mark J, Diehl Sean A, Yasuda Etsuko, Bakker Arjen Q, van Geelen Caroline M M, Lukens Michaël V, van Bleek Grada M, Widjojoatmodjo Myra N, Bogers Willy M J M, Mei Henrik, Radbruch Andreas, Scheeren Ferenc A, Spits Hergen, Beaumont Tim

Abstract excerpt

The B cell lymphoma-6 (Bcl-6) and Bcl-xL proteins are expressed in germinal center B cells and enable them to endure the proliferative and mutagenic environment of the germinal center. By introducing these genes into peripheral blood memory B cells and culturing these cells with two factors produced by follicular helper T cells, CD40 ligand (CD40L) and interleukin-21 (IL-21), we convert them to highly...

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Identifiers

PMID: 20023635
DOI: 10.1038/nm.2071
PMCID: PMC2861345

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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