Article
FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2010
Schildknecht Anita, Brauer Sabine, Brenner Corinne, Lahl Katharina, Schild Hansjörg, Sparwasser Tim, Probst Hans Christian, van den Broek Maries
Abstract excerpt
Peripheral T-cell tolerance is thought to significantly contribute to the prevention of autoimmunity, and it has been shown that antigen-presenting steady-state dendritic cells efficiently induce peripheral tolerance. We previously showed that dendritic-cell-induced tolerance is a T-cell-intrinsic process that depends on coinhibitory molecules such as programmed death-1. Here we specifically analyze the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.